Roche Hires Dr. John Reed to Lead Research Operations

The Swiss pharmaceutical giant Roche is turning to a prolific American academic scientist to revitalize its lagging research operations.

Dr. John C. Reed, the chief executive of the Sanford-Burnham Medical Research Institute in San Diego, will become head of Roche’s pharmaceutical research and early development group in April, the company announced Tuesday.

Dr. Reed, 54, has spent 21 years at Sanford-Burnham, formerly known as the Burnham Institute, the last 11 as chief executive.

During his tenure as chief executive, the institute grew rapidly, opened a new research site in Florida, and broadened its role from basic research to also doing drug discovery, in some cases in collaborations with pharmaceutical companies. It also received its largest donation ever, $50 million, from the credit card industry executive T. Denny Sanford, which led the institute to change its name.

Dr. Reed, 54, who holds both a medical degree and a Ph.D., is the author of more than 800 scientific papers, many dealing with why cancer cells do not commit suicide as errant cells are supposed to do. A triathlete, Dr. Reed used to get to his office around 3:30 a.m. each day, though now, with better computers, he works at home in the early hours.

“With his broad scientific and medical background, he is ideally positioned to drive Roche’s strategy of translating a better understanding of disease mechanisms into promising therapeutics,” Severin Schwan, the chief of Roche, said in a statement.

It is not unprecedented for drug companies to tap academic scientists to run research. Sanofi’s research and development is now run by Elias Zerhouni, the former director of the National Institutes of Health and professor at Johns Hopkins. Mark Fishman, a cardiologist at Harvard, was recruited to run research at Novartis, and Peter S. Kim, who heads research at Merck, was previously a biology professor at the Massachusetts Institute of Technology.

Dr. Reed, who has been on biotechnology company boards but never had a full-time corporate job, said in an interview that he was joining Roche to “have an opportunity to contribute on a larger stage, so to speak.”

At Roche he will oversee not only research but also early- and middle-stage clinical trials, something Sanford-Burnham does not do. He will supervise about 2,000 people with an annual budget in the billions, while Sanford-Burnham has about 1,200 people and a budget of around $175 million.

Dr. Reed, who will move to Basel, where Roche is based, said it was too early to discuss his agenda at Roche, other than to make its research more collaborative.

The operation Dr. Reed will run, called Pharma Research and Early Development, or pRED, does not include Genentech, the California biotechnology company that Roche fully acquired in 2009. In an effort to preserve the culture at Genentech, Roche left it autonomous, forming a group it calls gRED.

Recently, gRED has been eclipsing pRED. Roche’s three best-selling drugs, the cancer medicines Rituxan, Herceptin and Avastin, were developed at Genentech. So have some of its most attractive experimental drugs, including T-DM1, a breast cancer drug that could win regulatory approval early this year.

The organization Dr. Reed will run, by contrast, has had its share of problems in recent years. Several hundred researchers were cut in a corporate reorganization. And last year Roche discontinued development of a heart drug after it failed to work in a late-stage clinical trial.

The troubles contributed to Roche’s decision in June to shut its campus in Nutley, N.J., the birthplace of valium. At that time, Jean-Jacques Garaud, head of the Roche unit that Dr. Reed will run, left the company and was replaced on an interim basis by Mike Burgess. Roche said Tuesday that Mr. Burgess would now also leave the company.

Sanford-Burnham said that Dr. Kristiina Vuori, its president and head of its cancer center, would take over as chief executive on an interim basis. Dr. Vuori, who is originally from Finland, has worked closely with Dr. Reed.

M. Wainwright Fishburn Jr., the chairman of Sanford-Burnham, said it was “bittersweet” to see Dr. Reed leave. While the institute will lose a very successful leader, he said, the move could advance the institute’s efforts to get drug discovery work from pharmaceutical companies.

“We have one of our own in one of the most influential positions around,” he said.

This article has been revised to reflect the following correction:

Correction: January 15, 2013

A headline with an earlier version of this article misspelled the name of the drug maker. It is Roche, not Roches.

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An Anaheim woman demands respect for her neighborhood

Yesenia Rojas, vibrant in her purple shawl, sang with a voice so powerful it rose above the rest of the procession as they shuffled down the damp Anaheim sidewalk.

"Era mexicana. Era mexicana," they sang with a statue of Our Lady of Guadalupe hoisted high, candlelight and street lamps illuminating their way. "Madrecita de los mexicanos."

The singsong serenade lauds the patroness, the mother of all Mexicans.

On this drizzly evening, Rojas led the group down Anna Drive, where she and her family have made their home.

In a city often defined by Disneyland and elegant sports venues, this street of working-class Latino immigrants has become an avatar of a lesser-known, voiceless Anaheim, one riddled with poverty and gangs.

When police shot and killed a 25-year-old alleged gang member who lived on Anna Drive, it stoked what had been a growing fire in the city. It was the latest in a spate of police shootings last year, which inflamed anger with law enforcement into a larger sense of resentment over ethnic and class fissures that divide Orange County's largest city.

Unrest — amplified by Occupy-connected protesters from outside the city — gripped Anaheim for days after the July shooting, followed by weeks of heated City Council meetings.

The wave of protesters demanding change has washed away, but Rojas has emerged in its wake. The 35-year-old mother of six, with short, wavy dark hair and a small frame that belies her force of will, has taken it upon herself to become the voice of Anna Drive.

Her family lives in a one-bedroom apartment just yards from where Manuel Diaz was shot that summer day. Rojas' 14-year-old daughter saw Diaz's body and has been traumatized since. Her mother can't let that go.

"I thought about leaving, and so did my husband, because of the children," she said. "But I said no. Because, first of all, we don't need to fear anyone, not even the police. The biggest thing right now is to stay on our feet and make things happen as a community. If we all leave, things won't change. They'll keep trampling us and humiliating us."

Rojas has a vision for her community that would seem bold if her wishes weren't so simple: She imagines playgrounds and community centers and political representation. But most of all, she sees respect for Anna Drive.

She balances two jobs, but she makes time for her community. She bends the ears of politicians. She organizes rallies encouraging her neighbors to register to vote and head to the polls. She plans events that she hopes will draw together a community that has grown accustomed to seeing itself as the backdrop of news cameras trying to highlight the city's ills.

And on this night, dozens gathered to pray a rosario in the tight courtyard outside her apartment, where the statue of the Virgin rested on an altar of roses and carnations.

As sirens echoed in the distance, the crowd stayed late into the night. They sang, they danced, they sipped cinnamon-spiced coffee.

And they prayed, petitioning the Virgin Mother for peace and for guidance.

"This is the community," Rojas said. "These are the people of Anna Drive."

::

Anna Drive, a collection of squat, modest apartment buildings, horseshoes off of a busy thoroughfare. On any given day, it pulses with life: children whipping down the sidewalk on scooters and skateboards, older boys tussling with one another and nanas and tatas watching it all unfold from chairs in their frontyards.

The street is clogged with cars and the vending truck that always seems to be parked along the same slice of curb, hawking snacks, produce and spices to the families who live on this stretch of tidy apartments and small, fenced-in lawns.

Rojas came to Anna Drive about a year ago, moving her family into the tight but comfortable apartment, its walls lined with family photographs. She was born in the Mexican state of Guanajuato, but she has lived much of her life in the flatlands of Anaheim. Her mother has lived in the same apartment, just a few blocks away, for decades.

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CAD Designer Transforms <em>Halo</em> Chief Into Bobble Heads

Master Chief from the Halo series is one of the most fearsome computer-generated characters of all time, as well as a popular product license for everything from action figures to desk toys. When Funko licensed characters from the iconic Xbox franchise to make bobble heads, they recruited CAD/3-D printer artist Khurram Alavi to handle the mini-makeover.

Alavi grew up on a steady diet of animated shows and videogames from the ’80s and ’90s and dreamed of becoming a comic book artist. After earning a design degree in Pakistan, he joined a local animation firm where he discovered ZBrush, a powerful CAD package developed for the entertainment industry. “The world of 3-D just opened up to me,” says Alavi. “It was as if I was sketching, but with actual clay. I started using the software and began entering online contests. I won a few and managed to get some gigs with Marvel- and Sega-based characters.”

He went on to model characters from Star Wars and completed projects for Valve Software, but the Halo bobble head project proved to be more difficult to manage than an evil mutant or fearsome Street Fighter because it had to be cute. “Trust me when I say this — cute and small is not as simple as you may think,” says Alavi. “In fact, it is very challenging as the simplified forms and curvature need to be perfect in every way. I’ve spent days on the simplest of designs just to get the curves right.”

The character and a rough idea for a pose are all Alavi had to work with. “Funko sends over rough ideas for the pose and that’s about it.” says Alavi. “It’s my job to translate it and make it work in 3-D.” Funko also provided the original 3-D models used in Halo 4, but they were of limited use because of the differing requirements in videogames and design for manufacturing. “I could barely use those models as they were made for the game, but they did help speed up with sculpting process.” he says. “I was able to nail the costume elements and details very quickly.”

The model had to capture Masture Chief’s unique look, but was also required to be manufacturable at a low cost, which required great artistry from Alavi. “When you bring more than 40 individual costume elements into the mix, it gets far more complicated,” he says. “Then to make sure that the parts are thick and detailed enough and will be produced properly is another challenge within itself.”

In order to test his models, Alavi turned to 3-D printers and worked with a firm in Hong Kong called Ownage Manufacturing, which specializes in 3-D printing complex ZBrush models. “The approval process is usually very painful, with a lot of back and forth between myself and the licensor,” says Alavi. “They want their designs to be as accurate to the source material as possible, and rightly so. A one-week job can go up to two months sometimes in the collectibles business.”

Fortunately for Alavi, working in pixels has huge benefits over modeling with plasticine clay. “The digital sculpt is very fast in this respect as we can make changes very on the fly and takes less time when compared to making changes to a physical real world sculpture.”

CAD software and 3-D printers have essentially become a “reset” button for the real world.

Photos: Khurram Alavi

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Justin Timberlake releases ‘Suit & Tie,’ first single in 5 years

LOS ANGELES (Reuters) – Pop star Justin Timberlake unveiled on Sunday his first single in more than five years, “Suit & Tie,” featuring rapper Jay Z and producer Timbaland and said a new album would be released later in 2013.

Timberlake, 31 and newly married to actress Jessica Biel, had teased his fans last week with a cryptic tweet saying “I think I am ready” and linking to a video showing him walk into a studio.

Timberlake, a six-time Grammy winner and former member of boy band N’Sync, took a break from music after his 2006 album “Futuresex/Lovesounds” and worked as an actor in movies such as “The Social Network.”

He said in an open letter on his website that the new album is titled “The 20/20 Experience” but gave no further details.

(Reporting by Piya Sinha-Roy; Editing by Jon Boyle)

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Recipes for Health: Skillet Beet and Farro Salad

“Comforting” isn’t a word I usually associate with salads, but this week I put together five grain salads that fit that bill. Over the years I have developed a number of delicious whole grain salads that combine various grains with vegetables, herbs and often nuts, tossed in a tangy dressing. I have also married many a grain and vegetable in a pilaf. I decided to bring both concepts together in hearty salads that I’m calling “skillet salads;” each one is heated through in a skillet just before serving.

You can get ahead on all of these by cooking the grains or noodles ahead. Whole grains freeze well and keep in the refrigerator for three days. Then it’s just a question of preparing vegetables, herbs and dressing. Even if you don’t cook the grains ahead you can prepare the other ingredients while they’re simmering.

I make a meal of these at lunch, and serve smaller portions as sides or starters for dinner. If you want to serve the warm, tangy grains on a bed of salad greens I recommend spinach or sturdy greens like frisée or dandelion greens that will stand up to the heat of the salad and won’t wilt beyond recognition when topped with something warm.

Skillet Beet and Farro Salad

This hearty winter salad can be a meal or a side dish, and warming it in the skillet makes it particularly comforting. Cook your farro until you see that the grains have begun to splay so they won’t be too chewy and can absorb the dressing properly.

For the Salad:

2 medium or 3 small beets, roasted

1 cup farro, soaked for 1 hour in 1 quart water

Salt to taste

1 ounce lightly toasted pistachios (scant 1/4 cup)

1/4 cup chopped fresh herbs, such as parsley, tarragon, marjoram, chives, mint

Freshly ground pepper

For the Dressing:

2 tablespoons sherry vinegar

1 teaspoon balsamic vinegar

Salt to taste

1 small garlic clove, minced or pureéd

1 teaspoon Dijon mustard

1/3 cup extra virgin olive oil

2 tablespoons walnut oil

Crumbled feta for garnish (optional)

1. Roast the beets and meanwhile cook the farro. Place in a medium saucepan with the soaking water and bring to a boil. Add salt to taste, reduce the heat, cover and simmer 45 minutes to an hour, until the grains have begun to splay. Turn off the heat and allow to sit for 15 minutes or longer in the water. Drain through a strainer set over a bowl.

2. While the farro is cooking, make the vinaigrette. Whisk together the vinegars, salt, garlic, and mustard. Whisk in the oils. Pour into a wide frying pan or saucepan and add to the farro, along with a couple of tablespoons of the farro cooking water. Peel and dice the beets and add, along with the herbs and pistachios. Stir over medium heat until heated through and serve, with a little feta sprinkled over the top if you wish.

Yield: Serves 6

Advance preparation: The cooked farro and the roasted beats will keep for 3 or 4 days in the refrigerator.

Nutritional information per serving (6 servings): 304 calories; 19 grams fat; 2 grams saturated fat; 5 grams polyunsaturated fat; 11 grams monounsaturated fat; 0 milligrams cholesterol; 27 grams carbohydrates; 3 grams dietary fiber; 61 milligrams sodium (does not include salt to taste); 6 grams protein

Note: If you want to reduce the fat and calories in this dish, substitute buttermilk for some of the oil. Be careful not to allow the dressing to come to a boil when you heat it in the pan or the buttermilk will curdle.

Martha Rose Shulman is the author of “The Very Best of Recipes for Health.”

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DealBook: With U.P.S. Deal, European Antitrust Regulators Block Another Big Merger

European antitrust regulators proved again on Monday that they were more than willing to flex their considerable muscle.

U.P.S.‘s $6.9 billion bid for TNT Express is the latest merger blocked by the European Union, and certainly the most prominent since the proposed tie-up of NYSE Euronext and Deutsche Börse last year. In the case of U.P.S., European regulators argued that proposed asset sales, including airline operations, would not be enough to appease their concerns over the state of competitiveness in package delivery.

“We are extremely disappointed with the European Commission’s position,” the chief executive of U.P.S., D. Scott Davis, said in a statement. “We proposed significant and tangible remedies designed to address the European Commission’s concerns with the transaction.”

Other antitrust regulators have blocked mergers on antitrust grounds. For example, the Justice Department opposed AT&T‘s proposed $39 billion bid for T-Mobile USA.

But the European Commission, led by Joaquín Almunia, has displayed an aggressive approach that has rankled some deal makers.

Mr. Almunia has acknowledged those concerns, even as he has sought to rebut them. In a speech delivered in November, the commissioner argued that he was not trying to prevent European companies from growing. But he said he was trying to preserve a competitive market place.

“It is simply not true that the commission is putting the brakes on the legitimate efforts of Europe’s firms to scale up,” he said. “What we must avoid are attempts to shield Europe’s companies from competition, in particular during this harsh period for the economy. In this game, only a few of them will benefit, and the majority will lose.”

Among Mr. Almunia’s arguments was that the European Commission was less concerned about high levels of market share than what mergers might do to prices.

In the case of the NYSE Euronext merger, regulators demanded that the two exchange operators sell off significant parts of their businesses. Chief among the European Union’s concerns were the strong position that the two companies would have in the market for derivatives traded on exchanges, leading to a call for the sale of either NYSE Euronext’s Liffe platform or Deutsche Börse’s Eurex unit.

Both companies protested, arguing that the European Union’s view of the market was too limited and did not take into account the broader market for derivatives traded off exchanges. The market operators eventually decided to call off their deal, believing that there was little hope for reversing regulators’ opinion.

Other deals have passed review, but some have required significant changes. In approving Universal Music Group’s takeover of EMI Music last year, for example, European regulators required the sale of a third of EMI’s assets. The decision has led to the auction of music labels like Parlaphone, the home to groups like Coldplay and David Guetta.

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Egyptian court orders new trial for Mubarak

CAIRO—

An Egyptian court granted an appeal by former President Hosni Mubarak and ordered a new trial into the killings of hundreds of protesters during the 2011 uprising, a move certain to inflame the political unrest that has upset the country’s democratic transition.

The ruling was a victory for the ailing Mubarak and his Interior minister, Habib Adli, who also won his appeal. Both men, who had been sentenced to life in prison, face other criminal charges and are likely to remain in detention until a new trial in the deaths by security forces of more than 800 protesters.

“The previous ruling was unfair and illegal,” said Yousry Abdelrazeg, one of Mubarak’s lawyers, who accused the judge in the first trial of political bias. “The case was just a mess and there was no evidence against Mubarak.”

No date has been set for the new trial.

The court’s decision comes amid turmoil over an Islamist-backed constitution and outrage over the expanded powers of Islamist President Mohamed Morsi. It means a bloody chapter in Egypt’s 2011 revolt will be revisited with the prospect that Mubarak, whose police state ruled for 30 years, may be absolved in a case that deepened the nation’s political differences and impassioned the Arab world.

Mubarak was convicted in June of not preventing the deaths of hundreds of protesters attacked by police and snipers during the uprising, which began on Jan. 25, 2011, and ended 18 days later when he stepped aside and the military seized power.

Mubarak argued that he had not ordered the crackdown and was unaware of the extent of the violence. A recently completed government-ordered investigation into the killings, however, reportedly found that Mubarak had monitored the deadly response by security forces in Tahrir Square via a live television feed.

The appeals court ruling came a day after prosecutors announced an investigation into allegations that Mubarak, 84, received about $1 million in illicit gifts from Al Ahram, the country’s leading state-owned newspaper. The former president has reportedly been in a military hospital since December after he fell in a prison bathroom and injured himself.

Last year’s trial riveted the nation with images of the aging Mubarak wheeled into the defendant’s cage on a stretcher, his arms crossed and his eyes hidden behind sunglasses.

jeffrey.fleishman@latimes.com  

(Special correspondent Reem Abdellatif contributed to this report)

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<em>Firefly</em> Fan Tries to Retroactively Save Dead Character With NASA Data

Spoiler warning: Firefly ended over 10 years ago and it’s been 7 years since its subsequent film, Serenity, came out, so the spoiler statute of limitations is officially up. Proceed at your own risk.

Like many fans of the Joss Whedon space western Firefly, Kyle Hill was shocked by the end of the Serenity movie, when fan-favorite character Wash (Alan Tudyk) was unceremoniously impaled by a Reaver harpoon. Unlike most fans, Hill — a research assistant with a degree in Environmental Engineering and a contributor at Scientific American — decided to try and rewrite (fictional) history by proving that Wash’s death was scientifically impossible, using the power of math, physics and fandom. His article originally appeared online at Scientific American, and Wired publishes this updated version with permission.

I was late to Firefly. Nearly 10 years after the show first aired and then was subsequently cancelled, I holed up in my room, coffee and external hard drive in hand, aiming to blaze through one of the most beloved sci-fi series.

A mix of science fiction and “spaghetti-western” genres, Firefly was wonderful. It certainly awakened the fanboy in me, and I quickly understood why my girlfriend envied me for being able to watch the series for the first time.

It all ended abruptly, due to early cancellation, with the last episodes of Firefly barely answering any central questions or exploring the rich universe that had been so lovingly crafted by creator Joss Whedon. It was to my delight to learn that in 2005 there was a full-length movie in response to public (and private) outcries for more of Serenity and her crew.

Watching Serenity let me spend a bit more time in the ‘verse, and the film thankfully resolved a number of outstanding loops justwaiting to be closed. But the forced end of Firefly also forced Joss Whedon’s hand. He put in scenes that would only have appeared in a last hurrah like Serenity. One scene in particular shook me, like the unexpected sight of a Reaver ship. It’s a scene that drove me to NASA forums and technical reports, glass manufacturers, my calculator, and eventually to this post.

Late in Serenity, after crash-landing at the mysterious base of “Mr. Universe,” pilot Hoban “Wash” Washburne meets his end at the tip of a Reaver spear. The immediacy of the violence, and his wife Zoe’s touching reaction, kept my mouth agape well into the next few minutes of the film. One of my favorite characters just died, as Firefly died. I couldn’t stand it. I had to be sure.

What if the Reaver spear couldn’t plausibly make it through the forward windows of Serenity? The movie may have been set in the future, but we too have built spacecraft with windows, and they are made to withstand impacts. If I could prove that a modern shuttle window (assuming that a future window would be even better) could withstand the impact that killed Wash, I could have the ultimate in fanboy closure: the movie is “wrong,” and my version of the story lives on.

Objects in Space

In terrestrial situations, a speck of paint is less than harmless. In space, it’s deadly. Travelling at a blistering 10,000 meters per second in orbit, the equations deem it lethal. It becomes a “hypervelocity” bullet.

Our spacecraft obviously must account for this deadly debris. Tens of thousands of pieces of extraterrestrial trash litter the orbit of Earth [PDF], meaning that a shuttle’s final impact could come from an errant hex nut. Shuttles today are outfitted with shielding to prevent such disasters, and feature two-and-a-half inch thick windows—the thickest pieces of glass ever produced in the optical quality for see-through viewing.

The largest impact to a shuttle window occurred when a fleck of paint struck STS-92—a flight to the International Space Station. A shuttle window has never been penetrated by a hypervelocity impact, but it doesn’t have to be. A deformation large enough could eventually cause window failure upon repeated take-offs and re-entries.

After engineers examined the crater in the window of STS-92, the shape that best explained the damage was a sort of miniaturized plate. But to begin making comparisons, I’ll consider the fleck of paint to be a similarly sized metal sphere. This will bring the numbers in line with the hypervelocity testing that NASA has already conductBased on the size and the speed of the fleck that hit STS-92, I calculated that the window weathered an impact with around 20 Joules of kinetic energy—equivalent to four milligrams of TNT or a decently thrown baseball. It created more than enough damage to warrant a window replacement. And such replacements from serious impacts are commonplace. Robert Lee Hotz notes in the Wall Street Journalthat “NASA shuttle engineers have replaced the spacecraft’s debris-pitted windows after almost every flight since since 1981, at a cost of about $40,000 per window.”

 

Such little flecks can be catastrophes. An orbiter unlucky enough to be hit by anything much larger than the paint chip that hit STS-92 is in for some trouble. Debris measuring five centimeters in diameter packs the punch of a bus collision. Any larger than that and we begin making comparisons to sticks of dynamite.

The shuttle windows are tough, to be sure, surviving nearly 1,400 impacts intact over 43 sampled missions, but are they strong enough to save Wash? Tiny particles are elevated to terrifying status because of their ridiculous speeds, not their mass. Conversely, the Reaver spear that killed Wash was larger, but moving much more slowly. A few assumptions and some physics equations would determine if I could save him.

I Am A Leaf on the Wind…

To get the general dimensions of the spear that killed Wash, I had to (unfortunately) go back to the scene in question, excruciatingly slowing down an emotional moment to be replayed over and over.

Diving back into Serenity, I used an earlier Reaver chase scene to guesstimate the spear size and speed. If Reavers shoot spears slow enough to be dodged (which they do), the spear that kills Wash can’t be moving much faster than a Major League fast-ball, putting the upper limit on speed around 100 miles per hour (45 m/s). This is orders of magnitude slower than the hypervelocity impacts that a shuttle deals with, but the spear is thousands of times more massive than a fleck of paint. Assuming it’s fashioned out of an “average” metal, and given its size, I’d guess it’s around 100-200 pounds (45-90 kg).

Kinetic energy is easy enough to calculate. The kinetic energy of a moving object is one-half of its mass multiplied by the square of its velocity.

This equation gives the Reaver spear a frightening 45,500 Joules at the low end. This is over 3,700 times the energy of the largest recorded impact to a space shuttle window — equivalent to a detonation of a pencil made of TNT or a medium sized anvil dropped on it.

What are the risks? via Aerospace.org

Based on hypervelocity testing undertaken by NASA, the Reaver spear would be like an aluminum sphere with a one-centimeter diameter hitting the window at 10 kilometers per second (assuming that the tip of the spear is comparable to a 1cm diameter point). Seeing that the damage threshold for a shuttle window based on this testing is 0.004 centimeters, my hopes quickly vanished. With this kind of energy, the Reaver spear could pierce a shuttle’s wing, its thermal protection tiles, or even its crew cabin.

The math doesn’t lie—Wash didn’t stand a chance.

Watch How I Soar…

I thought I had found the perfect fanboy out. The windows in Serenity looked flimsy and thin, surely not something a space-faring craft would be outfitted with. If the windows were anything like what we use to traverse the ‘verse today, perhaps all that would have happened is a jolt of fright from a deflected Reaver spear, or so I hoped.

But even delving through a hundred page NASA technical report [PDF] on impact shielding couldn’t ease my psyche.

Now, this is at its core a fanboy rant. No matter what I found, Wash dies in the movie. It’s part of the larger story and serves as a plot point, not a meaningless killing-off. But I selfishly wanted closure; I needed to resolve the dissonance between a character’s death and the fact that we know he wouldn’t have died if the networks saw better numbers from Firefly.

Maybe this is a testament to the enduring qualities of the show. To create characters important enough, and in only fifteen short stories, to warrant hours of research and calculation that ultimately proves useless in the larger story is an outcome of a great narrative. It’s typical of a fan base that will still pack a Comic-Con panel ten years after the airing of the show.

In the end, I like the story better this way. It takes a great narrative to make someone care so much about a character that he takes real world steps to resolve his own dissonance. If I could have ‘proved’ that Wash wouldn’t have been killed, a whole can of worms would open. What about the fact that Serenity was an old ship with sub-optimal gear? What about space-age technologies like super-strong window polymers? The scene obviously resonated with people (especially me), and the fact that I failed is a better story than a discussion of faulty film physics.

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Gawker editor A.J. Daulerio leaving, John Cook to replace him

LOS ANGELES (TheWrap.com) – Gawker editor-in-chief A.J. Daulerio is leaving the site and reporter John Cook will replace him, Cook told TheWrap on Thursday.

Daulerio, who started at Gawker Media’s sports site Deadspin, oversaw the network’s flagship publication through a period of record growth.

“A.J.’s tenure at Gawker has been much like him: bold, infuriating, unpredictable… and often brilliant,” the site’s founder Nick Denton said in a staff memo, obtained by New York magazine. “I mean, I really don’t fully understand: AJ breaks all the usual rules of orthodox management and has still been the most successful editor of Gawker.com.”

Cook has long been one of the media gossip site’s most doggedly blunt writers and reporters. In August, he published a trove of hundreds of internal memos from Bain Capital, GOP presidential candidate Mitt Romney’s former private equity firm.

“John Cook is the most experienced reporter on the team, a surprisingly powerful opinion writer and a gossip of the most refined kind,” Denton wrote. “He has natural authority.”

It was not immediately clear when the management changes would take place.

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City Room: Cuomo Declares Public Health Emergency Over Flu Outbreak

With the nation in the grip of a severe influenza outbreak that has seen deaths reach epidemic levels, New York State declared a public health emergency on Saturday, making access to vaccines more easily available.

There have been nearly 20,000 cases of flu reported across the state so far this season, officials said. Last season, 4,400 positive laboratory tests were reported.

“We are experiencing the worst flu season since at least 2009, and influenza activity in New York State is widespread, with cases reported in all 57 counties and all five boroughs of New York City,” Gov. Andrew M. Cuomo said in a statement.

Under the order, pharmacists will be allowed to administer flu vaccinations to patients between 6 months and 18 years old, temporarily suspending a state law that prohibits pharmacists from administering immunizations to children.

While children and older people tend to be the most likely to become seriously ill from the flu, Mr. Cuomo urged all New Yorkers to get vaccinated.

On Friday, the Centers for Disease Control and Prevention in Atlanta said that deaths from the flu had reached epidemic levels, with at least 20 children having died nationwide. Officials cautioned that deaths from pneumonia and the flu typically reach epidemic levels for a week or two every year. The severity of the outbreak will be determined by how long the death toll remains high or if it climbs higher.

There was some evidence that caseloads may be peaking, federal officials said on Friday.

In New York City, public health officials announced on Thursday that flu-related illnesses had reached epidemic levels, and they joined the chorus of authorities urging people to get vaccinated.

“It’s a bad year,” the city’s health commissioner, Dr. Thomas A. Farley, told reporters on Thursday. “We’ve got lots of flu, it’s mainly type AH3N2, which tends to be a little more severe. So we’re seeing plenty of cases of flu and plenty of people sick with flu. Our message for any people who are listening to this is it’s still not too late to get your flu shot.”

There has been a spike in the number of people going to emergency rooms over the past two weeks with flulike symptoms – including fever, fatigue and coughing – Dr. Farley said.

Mayor Michael R. Bloomberg and Mr. Cuomo made a public display of getting shots this past week.

In a briefing with reporters on Friday, officials from the C.D.C. said that this year’s vaccine was effective in 62 percent of cases.

As officials have stepped up their efforts encouraging vaccinations, there have been scattered reports of shortages. But officials said plenty of the vaccine was available.

According to the C.D.C., makers of the flu vaccine produced about 135 million doses for this year. As of early this month, 128 million doses had been distributed. While that would not be enough for every American, only 37 percent of the population get a flu shot each year.

Federal health officials said they would be happy if that number rose to 50 percent, which would mean that there would be more than enough vaccine for anyone who wanted to be immunized.

Two other diseases – norovirus and whooping cough – are also widespread this winter and are contributing to the number of people getting sick.

The flu can resemble a cold, though the symptoms come on more rapidly and are more severe.

A version of this article appeared in print on 01/13/2013, on page A21 of the NewYork edition with the headline: New York Declares Health Emergency.

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